Alterations in cardiac macrophages in heart failure

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15437
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Chiba University
• Principal Investigator: MANABE Ichiro 千葉大学, 大学院医学研究院, 教授 (70359628)
• Research Collaborator: FUJIU Katsuhito 東京大学, 医学部附属病院, 特任助教 (30422306) ; MATSUMOTO Sahohime 千葉大学, 大学院医学研究院, 特任助教 (80570184) ; NAKAYAMA Yukiteru 東京大学, 医学部附属病院, 助教 (70721885)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: マクロファージ / 心不全 / エピジェネティクス

Outline of Final Research Achievements

Cardiac macrophages play various roles in the cardiac response to stress. In this study we hypothesized that the changes in cardiac macrophage function might contribute to the development of heart failure and that the changes might be regulated by the interaction between cardiac microenvironment and macrophages. We analyzed transcriptomes and epigenome in macrophages by RNA-seq and ATAC-seq and found that cardiac stress greatly altered epigenome in macrophages. We then identified several transcriptional regulatory motifs that may control epigenome in response to cardiac stress. We have also identified regulatory regions that respond to cardiac microenvironment and regulate cardiac macrophage-specific gene expression.

Free Research Field

循環器内科学