Elucidation of novel mechanism of phenotype synchronization among cardiomyocytes

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15441
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kyoto University
• Principal Investigator: Yamashita Jun 京都大学, iPS細胞研究所, 教授 (50335288)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: 細胞・組織 / 発生・分化 / シグナル伝達 / 循環器・高血圧 / 再生医学

Outline of Final Research Achievements

Previously, we succeeded in manipulating the velocity of cell differentiation from pluripotent stem cells. Recently, we found that differentiation velocity can be synchronized through unknown cell-cell communication mechanims. In this study, we demonstrated that exosome secreted from the cells mediates the differentiation synchronizing phenomenon.

Free Research Field

幹細胞生物学