2017 Fiscal Year Final Research Report
An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control
| Project/Area Number |
16K15443
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
YANO Masafumi 山口大学, 大学院医学系研究科, 教授 (90294628)
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| Co-Investigator(Kenkyū-buntansha) |
山本 健 山口大学, 大学院医学系研究科, 教授 (50363122)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | リアノジン受容体 / カルモジュリン / 心肥大 |
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| Outline of Final Research Achievements |
We found a mutation that strengthened the binding of CaM to RyR2 and created a knock-in (KI) mouse (CaM HA mouse) incorporating the mutant RyR2. Suppression of dissociation of CaM from RyR2 in dantrolene administered WT mice and CaMHA mice suppressed the Ca leak from RyR2 as well as that the hypertrophy of cardiomyocytes after TAC was significantly suppressed.
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| Free Research Field |
循環器内科学
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