2017 Fiscal Year Final Research Report
Anatomical and biochemical analyses of paprasympathetic ganglia in the pancreas
| Project/Area Number |
16K15486
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
TAKAHASHI Hironori 東北大学, 大学院医学系研究科, 大学院生
KAWANA Yohei 東北大学, 大学院医学系研究科, 大学院生
SUGAWARA Hiroto 東北大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 膵β細胞 / 迷走神経 / インスリン / 臓器連関 |
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| Outline of Final Research Achievements |
We previously reported a liver-brain-pancreas neuronal relay to play an important role in promoting pancreatic β cell proliferation. Here, we elucidated anatomical and biochemical mechanisms of the neuronal signals within the pancreas. First, the tissue clearing method, CUBIC, revealed a major part of parasympathetic ganglia to be located in the vicinity of pancreatic islets. In addition, ex vivo analyses showed that combined stimulation with several neurotransmitters released by vagal nerves enabled β cells to be efficiently proliferated. This neuronal signal-mediated mechanism, elucidated by this research program, holds potential for developing novel approaches to regenerating pancreatic β cells.
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| Free Research Field |
代謝学
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