2016 Fiscal Year Final Research Report
Development of anti-diabetic therapy by the elucidation of the mechanism linking microflora and adipose tissue macrophages
Project/Area Number |
16K15488
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | The University of Tokyo |
Principal Investigator |
Ueki Kohjiro 東京大学, 医学部附属病院, 客員研究員 (00396714)
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Project Period (FY) |
2016-04-01 – 2017-03-31
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Keywords | Akt / マクロファージ / インスリン / LPS |
Outline of Final Research Achievements |
We have found that LPS derived from microflora and insulin induced by feeding stimulates the production of IL-10 in adipose tissue macrophages, and that this production depends on the Akt-mTORC1 pathway. Indeed, mice with disiruption of Akt1 and Akt2 specifically in macrophage (MAktDKO mice) show impaired production of IL-10. MAktDKO mice exhibit impaired glucose tolerance with increased hepatic gluconeogenesis. Adenovirus-mdeiated gene transfer of IL-10 improves glucose tolerance with decreased hepatic gluconeogenesis in MAktDKO mice. Furthermore, MAktDKO mice show more weight gain under the normal chow diet compared to the control mice.
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Free Research Field |
糖尿病代謝内科学
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