New concept "subclinical central hypothyroidism"

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15493
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: Yamada Masanobu 群馬大学, 大学院医学系研究科, 教授 (90261833)
• Co-Investigator(Kenkyū-buntansha): 小澤 厚志 群馬大学, 大学院医学系研究科, 助教 (10573496) ; 佐藤 哲郎 群馬大学, 医学部附属病院, 講師 (40302484) ; 中島 康代 群馬大学, 医学部附属病院, 助教 (70707017)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 中枢性甲状腺機能低下症 / 潜在性 / TRHノックアウトマウス

Outline of Final Research Achievements

Subclinical hypothyroidism is drawing attention as a risk factor for the development of high LDL cholesterolaemia and cardiovascular disorders. We have discovered a new disease "subclinical central hypothyroidism" from the study of more than 300 pituitary tumors. Even in overt central hypothyroidism, the serum TSH level was within the reference range and can not be a diagnostic or therapeutic index. In this study, we have attempted to establish a diagnostic method to detect serum abnormal TSH using sample specimens and TRH knockout mice as model animals and finally investigate involvement of subclinical central hypothyroidism in lifestyle-related diseases .

Free Research Field

内分泌代謝学