2017 Fiscal Year Final Research Report
Identification and characterization of biological targets of chemical expander for hematopoietic stem cells
| Project/Area Number |
16K15507
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
Takubo Keiyo 国立研究開発法人国立国際医療研究センター, その他部局等, 生体恒常性プロジェクト長 (50502788)
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| Research Collaborator |
KOBAYASHI Hiroshi
MORIKAWA Takayuki
KARIGANE Daiki
TAMAKI Shinpei
HARAGUCHI Miho
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 造血幹細胞 |
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| Outline of Final Research Achievements |
Hematopoietic stem cells (HSCs) produce all the hematopoietic lineages after birth. HSCs are utilized for transplantation therapy for various hematological malignancies. Due to the limited source of donor HSCs, the development of HSC expansion method is highly required. Recently, several chemical expander for HSCs are reported. However, the endogenous targets for these expanders have not reported so far. In this study, we tried to identify the targets for the HSC expanders, and characterized the functions of the targets in hematopoietic stem cells.
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| Free Research Field |
血液学・幹細胞生物学
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