2017 Fiscal Year Final Research Report
Research for the mechanism of latency and immortalization of Epstein-Barr virus using haploid cells
| Project/Area Number |
16K15525
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
Kimura Hiroshi 名古屋大学, 医学系研究科, 教授 (30303621)
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 好隆 名古屋大学, 医学系研究科, 助教 (40754940)
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| Research Collaborator |
OKUNO Yusuke 名古屋大学, 医学部附属病院, 特任講師
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | EBV / HAP-1 / 溶解感染 |
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| Outline of Final Research Achievements |
Epstein-Barr virus (EBV) is associated with a variety of intractable infections and malignancies. HAP-1 cells, which have only one genome set, is suitable for genome screening. In this study, we tried screening of host genes to be associated with latency or immortalization of EBV using HAP-1 cells and next generation sequencing. We successfully generated HAP-1/EBV cells, but could not identify any host genes because of the lack in the maintenance of EBV.
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| Free Research Field |
ウイルス学
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