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2017 Fiscal Year Final Research Report

Myocardial fiber formation in the human fetus detected by diffusion tensor imaging

Research Project

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Project/Area Number 16K15535
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionKyoto University

Principal Investigator

Takakuwa Tetsuya  京都大学, 医学研究科, 教授 (40244933)

Co-Investigator(Kenkyū-buntansha) 原口 亮  兵庫県立大学, 応用情報科学研究科, 准教授 (00393215)
今井 宏彦  京都大学, 情報学研究科, 助教 (40506466)
山田 重人  京都大学, 医学研究科, 教授 (80432384)
Project Period (FY) 2016-04-01 – 2018-03-31
Keywordsヒト胎児 / 心臓 / 心筋走行 / MRI / DTI
Outline of Final Research Achievements

Histologic examination shows that myocardial fibers gradually change direction from endocardium to epicardium in adults. Little is known about the developmental process of such structures in the human fetus. The present study aimed to determine the development of myocardial structure with DTI using a 7T magnetic resonance imaging (MRI) system. Six fetal in vitro heart samples (CRL 71-160 mm) as well as 4 in vivo samples (CRL 50-90 mm) were obtained from the Congenital Anomaly Research Center, Kyoto University. The orientation of myocardial fibers in 12 regions in the anterior and inferior walls of the left ventricle and septum was analyzed. The helix angle, which indicates the orientation of the myofibers to the horizontal plane at each point, gradually increased from the endocardium to the epicardium in all 12 regions examined. The present data indicate that myocardial fiber formation in the left ventricle in the late first-trimester fetus is similar to that observed in adults.

Free Research Field

胎児医学

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Published: 2019-03-29  

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