Analysis of interacting-partners of Nav1.1 in premature mouse brain

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15564
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Nippon Medical School
• Principal Investigator: OGIWARA Ikuo 日本医科大学, 医学部, 准教授 (30373286)
• Co-Investigator(Renkei-kenkyūsha): KANEDA Makoto 日本医科大学, 大学院医学研究科, 教授 (30214480) ; ISHII Toshiyuki 日本医科大学, 医学部, 助教 (10643140) ; AKAGI Takumi 日本医科大学, 医学部, 助教 (50192878)
• Research Collaborator: USUI Sumiko ; Suzuki Chiaki
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: てんかん / ナトリウムチャネル / 脳・神経

Outline of Final Research Achievements

Dravet syndrome is an epileptic encephalopathy, mainly caused by mutations in the SCN1A gene encoding a voltage-gated sodium channel Nav1.1. This study was aimed to identify interacting-partners of Nav1.1. Using co-precipitation and tandem-mass spectrometry, this study reported three novel interacting-partners of Nav1.1 in premature mouse brain, which seemed to be expressed in inhibitory neurons as Nav1.1 did.

Free Research Field

神経科学