Development of a novel radiological-photo-therapy essential for Theranostics targeting deep lesions

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15582
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Okayama University
• Principal Investigator: MATSUURA Eiji 岡山大学, 中性子医療研究センター, 教授 (20181688)
• Co-Investigator(Renkei-kenkyūsha): KOBUCHI Hirotsugu 岡山大学, 大学院医歯薬学総合研究科, 講師 (10304297) ; TAKENAKA Fumiaki 岡山大学, 大学院医歯薬学総合研究科, 助教 (10642522)
• Research Collaborator: AKEHI Masaru 岡山大学, 大学院医歯薬学総合研究科, 助教 (50786738)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: Theranostics / Photodynamic Therapy / Cherenkov光 / Lactosome / Drug Delivery System

Outline of Final Research Achievements

Photodynamic therapy (PDT) using a photosensitizer capable of inducing cytotoxicity by light irradiation is effective only for the lesion closed to the body surface, due to low permeability of the near infrared light, and is ineffective for therapy targeting the deep tissues. To solve the problem, we studied using Cherenkov light generated by β+-ray emission of a PET nuclide as a internal light source. We have given the PDT effect by Cherenkov light to the innovative "Theranostics (a treatment and diagnostic enforcement) technology" consisting of the specific antibody/Zr-89 labeled-drug delivery system (DDS) that we have ever established. We were newly able to verify some of the new basic technologies to overcome the problem (limit) of the PDT effect.

Free Research Field

放射線化学、臨床検査学、病態医化学