2017 Fiscal Year Final Research Report
Design of injectable gel with NO releasing properties and its application
| Project/Area Number |
16K15628
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 一酸化窒素 / インジェクタブルゲル / 心筋梗塞 / 虚血性疾患 / アルギニン / 誘導型一酸化窒素合成酵素 / ブロック共重合体 / フラワーミセル |
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| Outline of Final Research Achievements |
NO generation ability was installed in nanoparticles which forms gel under the physiological conditions. The obained NO-release injectable gel was administered to the myocardial infarction region and the formed gel in myocardium improves long-term retention and continuous generation of NO and increases blood flow and new blood vessels. The objective of this work was to improve angiogenesis of myocardial infarction using our NO-releasing injectable gel. In addition, an ROS elimination function was added to the NO-releasing injectable gel, which avoided consumption of the generated NO and improved therapeutic efficacy.
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| Free Research Field |
生体機能材料
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