Functional analysis of cartilage glycans for the elucidation of osteoarthritis pathomechanisms

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15650
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Iwasaki Norimasa 北海道大学, 医学研究科, 教授 (30322803)
• Co-Investigator(Kenkyū-buntansha): 小野寺 智洋 北海道大学, 大学病院, 講師 (70547174)
• Research Collaborator: HOMAN Kentaro 北海道大学, 大学院医学研究院, 博士研究員 (40823331)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 骨・軟骨代謝 / 糖鎖

Outline of Final Research Achievements

Our hypothesis was that early osteoarthritic cahnges induced by alterations in cartilage glycans would be reversible. To test this hypothesis, we created in vivo and in vitro early osteoarthritic models based on alpha-mannosidase administration. The administration of alpha-mannosidase induced early osteoarthritis in in vivo and in vitro models. Additionally, this histological changes were recovered by the discontinuation of alpha-mannosidase adminiatrations. Future studies will be performed to clarify this recovery mechanism in early osteoarthritis pathogenesis.

Free Research Field

整形外科