Myogenic potency of human satellite cells from torn muscles

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15651
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tohoku University
• Principal Investigator: Hagiwara Yoshihiro 東北大学, 医学系研究科, 准教授 (90436139)
• Co-Investigator(Kenkyū-buntansha): 神崎 展 東北大学, 医工学研究科, 准教授 (10272262) ; 土谷 昌広 東北福祉大学, 健康科学部, 准教授 (60372322)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 筋前駆細胞 / 脂肪浸潤 / 関節鏡手術 / 腱板断裂 / 脂肪前駆細胞

Outline of Final Research Achievements

Rotator cuff tear is a common disease in elderly patients that leads to shoulder weakness, pain, and disability in the activities of daily living. Some patients with massive rotator cuff tears have an unacceptable clinical outcome because of muscle atrophy and fatty infiltration. The satellite cell has central role of muscle regeneration, however, there are few reports about human muscle. The purpose of this study was to compare in vivo features of human myogenic and adipogenic precursors in the rotator cuff muscles in both torn supraspinatus (SSP) and intact subscapularis (SSC) tendons. The human satellite cells from the SSP muscle with fatty infiltration maintained intrinsic myogenic potentials.

Free Research Field

整形外科