Identification of the cell-of-origin of ectopic bones using lineage tracing mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15662
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: Ikeya Makoto 京都大学, iPS細胞研究所, 准教授 (20442923)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Yasuhiro 京都大学, iPS細胞研究所, 教授 (70313872)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 異所性骨化

Outline of Final Research Achievements

Fibrodysplasia Ossificans Progressiva (hereafter refer as FOP) is an intractable rare disease. In FOP patients, ectopic bones gradually appears in connective tissues such as muscles, tendons, and ligaments, and the cell-of-origin the ectopic bones were not clear. In this application, we hypothesized that neural crest cells are one of the origins of ectopic bone of FOP. By using genetically modified lineage tracing mice, we have succeeded to obtain an preliminary results that support this hypothesis.

Free Research Field

整形外科学