2017 Fiscal Year Final Research Report
Calcium homeostasis regulation by intestinal mechano-stress sensor
| Project/Area Number |
16K15665
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
Maruyama Kenta 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (60724119)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 骨代謝 / メカノストレス |
|---|
| Outline of Final Research Achievements |
The mechano-stress sensor X (alias) is expressed in intestinal epithelium. Deletion of mechano-stress sensor X in the intestinal epithelium leads to increased bone volume. This result suggests that intestinal mechano-stress sensor activation suppresses bone formation. The novel gut-bone homeostasis machinery is now under investigation.
|
| Free Research Field |
骨代謝学
|
