2017 Fiscal Year Final Research Report
The study to develop a therapeutic method for PTSD with opiate
| Project/Area Number |
16K15679
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKASE Kenkichi 自治医科大学, 医学部, 教授 (80381474)
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| Research Collaborator |
KOBAYASHI Ayako 横浜市立大学, 医学部, 指導診療医
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | オピオイド / AMPA受容体 |
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| Outline of Final Research Achievements |
A ultra-short acting opiate, remifentanil, promoted the dephospholyration of hippocampal AMPA receptors in a dose-dependent manner, leading to the reduction of membrane AMPA receptors. Furthermore, this phenomenon was mediated by protein phosphatase1. In vivo manipulation to promote the dephospholyration of hippocampal AMPA receptors could erase fear memory in the rats.
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| Free Research Field |
神経科学
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