2017 Fiscal Year Final Research Report
Investigation of the mechanism how dietary foods influence on progression of ovarian cancer.
| Project/Area Number |
16K15707
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kindai University (2017)
Kyoto University (2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安彦 郁 京都大学, 医学(系)研究科(研究院), その他 (20508246)
越山 雅文 京都大学, 医学研究科, 客員研究員 (50724390)
小西 郁生 京都大学, 医学研究科, 名誉教授 (90192062)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 卵巣癌 / 食品 |
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| Outline of Final Research Achievements |
We evaluated whether different dietary protein qualities (isocaloric diets involving animal or plant protein) could inhibit the ovarian cancer growth in mice. In the mice of the 20% plant protein group, the ovarian cancer growth was reduced in comparison to the mice in the 20% animal protein group. The serum levels of insulin and IGF-1 levels were both lower in the mice of the 20% plant protein group than in the mice of the 20% animal protein group. Immunohistochemistry revealed that the level of p-4EBP1 (one of the major downstream effectors of the mTOR pathway) of the plant protein group was weaker than that of the animal protein group. Our findings suggest that a diet high in plant protein reduces the growth of human ovarian cancer cells in mice compared to a diet high in animal protein, possibly through the lack of activation of the IGF/Akt/mTOR pathway.
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| Free Research Field |
gynecological cancer
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