Establishment tailor-made therapy of head and neck cancer by single cell analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15718
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: Satoru Kondo 金沢大学, 附属病院, 講師 (70436822)
• Co-Investigator(Kenkyū-buntansha): 吉崎 智一 金沢大学, 医学系, 教授 (70262582)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: シングルセル / 血中循環腫瘍細胞 / EpCAM

Outline of Final Research Achievements

Cancer tissues have various heterogeneity and very few cells indicate its phenotypes of cancer. This variety leads difficulty of assessment of cancer phenotypes by ordinal methods such as PET, miRNA and microarray. Exact assessment of cancer phenotypes is necessary to determine groups which has highly malignant cancer cells. From this aspect, we focused circulating tumor cell (CTC). Because CTC has capacity of high invasion and metastasis. So CTC is considered to reflect cancer grades and phenotypes. In this study, we focused CTC and analyzed detection of CTC.

Free Research Field

耳鼻咽喉科