2017 Fiscal Year Final Research Report
Development of novel treatment and prevention for chronic eosinophilic rhinosinusitis using myeloid-derived suppressor cells.
| Project/Area Number |
16K15721
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 好酸球性副鼻腔炎 / 骨髄由来免疫抑制細胞 / プロスタグランジンE2合成酵素 |
|---|
| Outline of Final Research Achievements |
As compared with uncinate process mucosa, nasal polyp (NP) showed higher expression of myeloiod-derived suppressor cells (MDSC). In addition, NP from eosinophilic chronic rhinosinusitis (ECRS) showed higher expression of MDSC as compared with NP from non-ECRS. Moreover,lineage (-) HLA-DR (-) CD33 (+) MDSC showed higher expression of prostaglandin E2 synthetase-1 (PGES-1) mRNA as compared with lineage (-) cells as well as lingeage (-) HLA-DR (+) cells.
These results suggest that MDSC are involved in pathogenesis of ECRS via expression of PGES-1.
|
| Free Research Field |
耳鼻咽喉科
|
