Stem cell homing for inner ear cell therapy with iPS cell

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15725
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Juntendo University
• Principal Investigator: KAMIYA Kazusaku 順天堂大学, 医学部, 准教授 (10374159)
• Co-Investigator(Kenkyū-buntansha): 福永 一朗 順天堂大学, 医学(系)研究科(研究院), 助教 (20746581)
• Research Collaborator: MINOWA Osamu ; FUZIMOTO Ayumi ; HATAKEYAMA Kaori
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 内耳 / ホーミング / 幹細胞 / 移植 / ケモカイン / 蝸牛

Outline of Final Research Achievements

Inner ear cell therapy for sensorineural hearing loss has been expected to be an effective therapy for hereditary deafness. We developed a strategy for inner ear cell therapy using bone marrow mesenchymal stem cells (MSC) and established the differentiation method for inner ear like cells from induced pluripotent stem (iPS) cell. For cell therapy targeting hereditary deafness, a more effective cell delivery system to induce the stem cells into cochlear tissue is required. Stem cell homing is one of the crucial mechanisms to be activated for efficient cell delivery to the cochlear tissue. In our study, MCP-1, SDF-1 and their receptors were found to be a key regulator for stem cell recruitment to the cochlear tissue. By activating stem cell homing, we developed a novel strategy to induce a number of stem cells into cochlear tissue.

Free Research Field

細胞生物学