2016 Fiscal Year Final Research Report
Establishment for the treatment targeted collagen-producing cells in fibroproliferative scar
| Project/Area Number |
16K15753
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Keywords | 細胞系譜追跡 |
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| Outline of Final Research Achievements |
We established a transgenic mouse line in which we could trace the fate of hematpoietic stem cells with tdTomato and visualize collagen type 1-producing cells with EGFP. In hypertrophic scar model using the mice, all collagen type 1-producing cells derived from hematopoietic stem cells. Next, we tried profiling the cell in hypertrophic scars with flow cytometry, but failed due to lack of the transgenic mice. So, we re-established a transgenic mouse line to gain enough number of the mice.
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| Free Research Field |
形成外科学
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