Pathophysiological significance of two types of DAMPs, naked- and exosomal type.

2016 Fiscal Year Final Research Report

• Project/Area Number: 16K15763
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Kagoshima University
• Principal Investigator: MARUYAMA Ikuro 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Keywords: DAMPs / HMGB1 / Exosome / DIC / ARDS / Organ failure

Outline of Final Research Achievements

Damage associated molecular patters, DAMPs, are released from the damaged or stimulated cells and act on various types of cells through toll like receptors. These result the various cellular events including inflammasome activation. We investigated the molecular and cellular basis of DAMPs. We showed that DAMPs released from the cells by free molecular form, and/or enwrapped into the exosome. We identified that there are two types of DAMPs, naked, free molecule form and exosomal form.
In this project, we investigated the pathophysiological differences among two types of DAMPs, histones and HMGB1.We showed that HMGB1 was mainly present with the naked form. However in the case of histones, there are two types, naked and exosomal types. These may explain that exosomal histones are targeted to the remote organs resulting organs damages, including ARDS. However, naked HMGB1 may circulate and play roles for the development of systemic pathologic states including DIC.

Free Research Field

血液凝固学、生体侵襲学