• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2017 Fiscal Year Final Research Report

Basic research for development of effective inducing strategy of sublingual immune tolerance

Research Project

  • PDF
Project/Area Number 16K15772
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Morphological basic dentistry
Research InstitutionTohoku University

Principal Investigator

SUGAWARA Shunji  東北大学, 歯学研究科, 教授 (10241639)

Co-Investigator(Kenkyū-buntansha) 黒石 智誠  東北大学, 歯学研究科, 講師 (30400261)
Co-Investigator(Renkei-kenkyūsha) TANAKA Yukinori  JSPS, 特別研究員(PD) (60637958)
Research Collaborator LU Lu  
SHISHIDO Kaori  
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords免疫寛容 / 舌下免疫
Outline of Final Research Achievements

Sublingual immunotherapy (SLIT) is an allergen-specific treatment for allergy. SLIT increases allergen tolerance with safety and effective effect. However, the effect is not always strong enough, strategy to increase SLIT is anticipated. This study aimed at finding a substance that augment the effect of SLIT by using delayed-type hypersensitivity mouse mode. Among candidate substances that can induce regulatory T cells, we succeeded to find out one substance (referred to substance A). SLIT enhancing effect by substance A was long-lasting, but production fo retinoic acid by sublingual mucosal dendritic cells. We are still challenging to elucidate the underlying mechanism.

Free Research Field

口腔免疫学

URL: 

Published: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi