Identification of the target genes of glucocorticoid receptor in the pathogenesis of steroid-induced osteoporosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15781
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KOMORI Toshihisa 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00252677)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: グルココルチコイド / ステロイド性骨粗鬆症 / Fkbp5 / 骨形成 / 骨吸収

Outline of Final Research Achievements

Steroids are effective drugs for inflammatory diseases and autoimmune diseases. However, steroids most frequently induce secondary osteoporosis. The risk of bone fracture in the patients with steroid treatment is about 30-50%. Trabecular bone is reduced and the fractures of vertebral body and femoral neck occur in the patients with steroid treatment. Fkbp5 is a shaperon molecule of glucocorticoid receptor, and Fkbp5 knockout mice showed severely reduced bone formation by glucocorticoid treatment. We tried to identify the target genes of glucocorticoid receptor, which are responsible for steroid-induced osteoporosis, using Fkbp5 knockout mice.

Free Research Field

生物系学、骨代謝学、歯学