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2017 Fiscal Year Final Research Report

Preliminary investigation of optimal cell culture condition of circulating tumor cells

Research Project

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Project/Area Number 16K15786
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionUniversity of Yamanashi

Principal Investigator

SAITOH Masao  山梨大学, 大学院総合研究部, 教授 (90345041)

Research Collaborator SAKAMOTO Kei  
SAKAMOTO Kaname  
NAKAMURA Ryosuke  
HOTTA Asami  
FURUYA Satoshi  
Project Period (FY) 2016-04-01 – 2018-03-31
KeywordsEMT / CTC / TGF-beta
Outline of Final Research Achievements

During EMT in cancer progression, cancer cells that originate from epithelial cells exhibit both mesenchymal and epithelial characteristics, known as partial EMT. Partial EMT in cancer cells is thought to enhance their invasive properties, generate circulating tumor cells(CTC) and cancer stem cells, and promote resistance to anti-cancer drugs. We found that partial EMT is dramatically in cancer cells by overexpression of a certain gene (geneX). The cancer cells undergoing partial EMT promote invasive properties and resistance to anoikis as determined by equipments developed by us. Thus, we are further investigating the roles of the cells in CTC by in vitro experiments and mouse in vivo models.

Free Research Field

がん生物学

URL: 

Published: 2019-03-29  

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