2017 Fiscal Year Final Research Report
Establishment of system for predicting inflammatory diseases
| Project/Area Number |
16K15788
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Nishimura Riko 大阪大学, 歯学研究科, 教授 (60294112)
Hata Kenji 大阪大学, 歯学研究科, 准教授 (80444496)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 炎症 / 代謝物 |
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| Outline of Final Research Achievements |
Activation of inflammasome was strongly suppressed by proteasome inhibition. This result strongly suggested that proteins degraded by the proteasome are involved in inflammasome activation. Therefore, we analyzed proteins secreted from cells in response to inflammasome activation by mass spectrometry. Many proteins were detected by mass spectrometry, indicating that there is a possibility that these proteins are useful as novel markers for predicting diseases related to inflammasome.
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| Free Research Field |
分子細胞生物学
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