2017 Fiscal Year Final Research Report
Control of pulpal inflammation and hard tissue regeneration by miR-21, a modulator of cross-talk between inflammation and tissue regeneration
| Project/Area Number |
16K15795
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAWASHIMA Nobuyuki 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60272605)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | dental pulp cell / micro RNA / miR-21 / NFkB signaling / inflammation / LPS / signaling cascade / differentiation |
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| Outline of Final Research Achievements |
miR-21 was up-regulated in the inflamed rat dental pulp tissue, and lipopolysaccharides induced expression of miR-21 in the human dental pulp cells. miR-21 down-regulated NFkB signaling via degradation of TNF receptor-associated factor (TRAF) 6 and programmed cell death (PDCD) 4. miR-21 also promoted osteopontin expression. miR-21 may control the progress of pulpal inflammation and modulate the hard tissue formation in the dental pulp tissue.
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| Free Research Field |
歯内療法学
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