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2017 Fiscal Year Final Research Report

Chronic muscle pain pathophysiology from the viewpoint of mitochondria dysfunction

Research Project

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Project/Area Number 16K15801
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Research InstitutionOkayama University

Principal Investigator

MAEKAWA KENJI  岡山大学, 医歯薬学総合研究科, 准教授 (20304313)

Co-Investigator(Kenkyū-buntansha) 大野 充昭  岡山大学, 医歯薬学総合研究科, 助教 (60613156)
水口 一  岡山大学, 大学病院, 講師 (30325097)
窪木 拓男  岡山大学, 医歯薬学総合研究科, 教授 (00225195)
Project Period (FY) 2016-04-01 – 2018-03-31
Keywords慢性筋痛 / 疾患感受性 / ビタミンD
Outline of Final Research Achievements

We made an attempt to elucidate the relationship between vitamin D function and muscle pain. This hypothesis was established based on the several previous reports, which describe the positive relationship between taking antilipemic and muscle pain onset, especially seen in hyperlipidemia patients with vitamin D deficiency.
As the results, gene expression levels of vitamin D receptor was significantly higher in trapezius and masseter muscles, which are easily affected by muscle pain than limb muscles, which are not very sensitive to muscle pain. These results suggest the possible relationship between vitamin D function and muscle pain. In addition, expression levels of positive cell number of pain sensitivity marker (c-fos) in central nervous system under noxious stimulus application in masseter muscle tended to be higher in vitamin D deficiency rats than those in rats without vitamin D deficiency.

Free Research Field

医歯薬学

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Published: 2019-03-29  

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