Effect of Osteopontin Derived Peptide on Palatal Surgery

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15821
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: Kogo Mikihiko 大阪大学, 歯学研究科, 教授 (20205371)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 口蓋裂 / 骨格筋 / オステオポンチン / SV / 再生

Outline of Final Research Achievements

In order to establish a new treatment method for skeletal muscle damage of soft palate using experimental animals, SV peptide was examined using physiological functional evaluation and morphological evaluation The effect of the regeneration healing of the damaged skeletal muscle. The administration of the SV peptide is activated the self-regeneration ability of skeletal muscle, it is shown to work significantly in the functional recovery after muscle damage, it was suggested that it is possible to become one of the effective muscular function regeneration treatment. An histological study was conducted on the effect of the SV peptide on the regeneration restoration process. SV peptide proliferative capacity of the muscle bud cells, migration ability, the movement ability is activated, and by increasing the expression of myogenin which is a muscle tube cell differentiation inducing factor, skeletal muscle regeneration has been suggested to be promoted.

Free Research Field

口腔外科学