Wound healing and mechxnosensitive ion channel

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15825
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Saga University
• Principal Investigator: Kido Mizuho 佐賀大学, 医学部, 教授 (60253457)
• Co-Investigator(Kenkyū-buntansha): 合島 怜央奈 佐賀大学, 医学部, 助教 (30756143)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 創傷治癒 / 上皮細胞 / 細胞間接着

Outline of Final Research Achievements

Skin or oral wounding is great burden for patients and faster wound repair is always desired. Oral mucosa is always exposed to various stimuli and at the same time it has high turnover rate and recover faster than the skin wound. We focused mechanosensitive calcium permeable channel, because oral mucosa is always exposed to mechanical stimuli. We focused transient receptor potential channel vanilloid 4, which is activated by warm temperature, mechanical stretch, and hypo-osmolarity. We found out using TRPV4 deficient mice that wound healing is affected by TRPV4 activation. We propose here TRPV4 may one of the candidate for wound healing treatment.

Free Research Field

口腔解剖学