Translational research to overcome chromosomal abnormality using deciduous teeth

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15839
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Kyushu University
• Principal Investigator: Nonaka Kazuaki 九州大学, 歯学研究院, 教授 (90128067)
• Co-Investigator(Kenkyū-buntansha): 佐藤 浩 九州大学, 歯学研究院, 助教 (00421313) ; 加藤 大樹 九州大学, 医学(系)研究科(研究院), 研究員 (30452709) ; 廣藤 雄太 九州大学, 歯学研究院, 助教 (80759746) ; 山座 治義 九州大学, 歯学研究院, 准教授 (30336151) ; 増田 啓次 九州大学, 大学病院, 講師 (60392122)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: ダウン症 / ゲノム編集 / 乳歯由来幹細胞

Outline of Final Research Achievements

We examined the pathology of down syndrome using stem cells from human exfoliated deciduous teeth (SHED) derived from a patient with down syndrome. Furthermore, we attempted to develop a system to eliminate excess chromosome 21 by genome editing. We revealed that neurodevelopment ability of SHED derived from a patient was lower than SHED derived from a typically developing child. In addition, we established a system to eliminate a targeted chromosome.

Free Research Field

小児歯科学