2017 Fiscal Year Final Research Report
Human genome analysis for impacted supernumerary teeth in the region of maxillary incisor
| Project/Area Number |
16K15843
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 正皓 昭和大学, 歯学部, 助教 (10736713)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 過剰歯 / 遺伝子 / 全エクソンシーケンス / 家系 |
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| Outline of Final Research Achievements |
One of the popular disorders commonly found in human dentition is the existence of supernumerary teeth. In the present study, we conducted whole-exome sequencing of supernumerary teeth in non-syndromic Japanese individuals to identify the susceptible genes and / or loci. In this study, we selected four Japanese families, two families with the first and the second generation have supernumerary teeth and the other two families have the second generation only with supernumerary teeth. Moreover, 14 sporadic Japanese individuals with impacted supernumerary teeth in the maxillary incisor area were included in the sample. We identified some candidate genes for supernumerary teeth in Japanese individuals.
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| Free Research Field |
歯科矯正学
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