The trial of clarification of the mechanism of salivary hypofunction involved in cancer therapies and development the care for protection of salivary glands by producing a model mouse.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15863
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fundamental nursing
• Research Institution: Yamagata University
• Principal Investigator: Sekimata Akiko 山形大学, 医学部, 准教授 (50321823)
• Co-Investigator(Kenkyū-buntansha): 関亦 正幸 福島県立医科大学, 医学部, 准教授 (80250190) ; 野川 宏幸 千葉大学, 大学院理学研究院, 准教授 (40143250)
• Research Collaborator: NOGAWA Hiroyuki ; INOUE Naokazu ; YOSHIDA Daiki ; HAYASAKA Yuto ; SUINA Yumi
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 唾液腺 / 唾液分泌低下 / 放射線療法 / がん化学療法 / がん支持療法

Outline of Final Research Achievements

Hyposalivation as a consequence of cancer therapies is the significant complication, because hyposalivation causes various side effects such as oral trouble, reducing illness motivation, including danger of life. This study aimed at clarification of the mechanism of salivary hypofunction involved in cancer therapies and development the care for protection of salivary glands, by producing a transgenic mouse introduced Venus gene which is enabled visualization and quantification of saliva secretion. We successfully produced the transgenic mouse and in vitro salivary gland culture-systems in this study. In future, we would like to contribute to the development of supporting treatments for cancer therapies by the identification of protectants for salivary glands and promoters for saliva secretion using the transgenic mouse and the culture systems.

Free Research Field

基礎看護学、細胞生物学