Research and development of screening method using phenotype and genotype in early stage COPD

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16148
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Life / Health / Medical informatics
• Research Institution: The University of Tokushima
• Principal Investigator: Suzuki Hidenobu 徳島大学, 大学院社会産業理工学研究部理工学域, 助教 (50546710)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 慢性閉塞性肺疾患 / 医用画像 / ゲノム / 検診法 / イメージングバイオマーカー

Outline of Final Research Achievements

This research project aims to contribute to improvement of QOL for COPD patients by researching and developing screening method using phenotype and genotype at early stage of COPD. LAV (low-attenuation volume), which is an index of the emphysema progression, was automatically measured using CT images of smokers, past smokers, and nonsmokers. We calculated the annual increment of LAV for about 5 years and classified the participants into two groups, COPD risk group / non-risk group. We found candidate SNPs (Single Nucleotide Polymorphism) related to the COPD risk group and found the possibility of a new screening method in eary stage COPD.

Free Research Field

医用画像処理