Elucidation of useful livestock/poultry for Pb source estimation and its molecular mechanisms underlying species differences by integrated metallomics approaches

2017 Fiscal Year Annual Research Report

• Project/Area Number: 16K16197
• Research Institution: Hokkaido University
• Principal Investigator: 中山 翔太 北海道大学, 獣医学研究院, 助教 (90647629)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 鉛 / 汚染源推定 / 安定同位体比 / 家畜・家禽 / 歩哨動物 / LA-ICP-MS / 海馬 / 高感受性部位

Outline of Annual Research Achievements

途上国を中心に、年間23万人が主に鉱床由来の鉛中毒により死亡し、60万人以上の子供の知的発達に影響を及ぼしているが、汚染源推定に有用な手法は確立されていない。鉛の生体内同位体分別により、低濃度暴露においては、人の血液・尿の鉛同位体比解析による推定が困難なためである。そこで、本研究では鉛汚染源推定に有用な家畜・家禽種を解明することを目的とした。鉛汚染地域であるザンビア・カブエ鉱床地域において、家畜・家禽であるヤギとニワトリを採材し、血液や臓器中の鉛同位体比をマルチコレクター誘導結合プラズマ質量分析計により高性能分析を実施した。土壌などの環境試料における同位体比とのマッピングおよび室内実験での鉛投与試験により、アフリカを含めた発展途上国で流通し、またヒトの食糧源としても用いられるこれらの家畜・家禽を用いることで、鉛汚染源の推定が可能であることを明らかにした。さらに、LA-ICP-MS（レーザー照射型 誘導結合プラズマ質量分析法）により、マウスにおける鉛の臓器内局所分布を解析した。脳の海馬領域の高濃度蓄積や、特に、腎臓の髄質において皮質よりも高濃度の鉛蓄積が確認された。鉛や他の有害金属の腎障害は、主に皮質に存在する近位尿細管に生じるため、近位尿細管（皮質）の高濃度蓄積を予想していたが、本研究結果は、高感受性部位と高蓄積部位は異なるということを示唆し、鉛の病理毒性学的な機序解明に貢献する知見である。以上の成果は、学術論文や国内外の学会で発表し、国際シンポジウムでの受賞など高い評価も受けている。さらに、当該研究課題は、平成30年度からの国際共同研究加速基金（国際共同研究強化）の新規課題に発展・拡大し、ザンビア大学との継続的な共同研究へと繋がった。

Research Products

• [Int'l Joint Research] ザンビア大学(ザンビア)
  • Country Name: ZAMBIA
  • Counterpart Institution: ザンビア大学
• [Int'l Joint Research] クワメエンクルマ科学技術大学(ガーナ)
  • Country Name: GHANA
  • Counterpart Institution: クワメエンクルマ科学技術大学
• [Int'l Joint Research] ベニン大学(ナイジェリア)
  • Country Name: NIGERIA
  • Counterpart Institution: ベニン大学
• [Int'l Joint Research] ノースウェスト大学(南アフリカ)
  • Country Name: SOUTH AFRICA
  • Counterpart Institution: ノースウェスト大学
• [Int'l Joint Research] ゴンダ大学(エチオピア)
  • Country Name: ETHIOPIA
  • Counterpart Institution: ゴンダ大学
• [Journal Article] Lead and cadmium excretion in feces and urine of children from polluted townships near a lead-zinc mine in Kabwe, Zambia (2018)
  • Author(s): Yabe John、Nakayama Shouta M.M.、Ikenaka Yoshinori、Yohannes Yared B.、Bortey-Sam Nesta、Kabalo Abel Nketani、Ntapisha John、Mizukawa Hazuki、Umemura Takashi、Ishizuka Mayumi
  • Journal Title: Chemosphere Volume: 202 Pages: 48～55
  • DOI: https://doi.org/10.1016/j.chemosphere.2018.03.079
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accumulation patterns and risk assessment of metals and metalloid in muscle and offal of free-range chickens, cattle and goat in Benin City, Nigeria (2018)
  • Author(s): Ogbomida Emmanuel Temiotan、Nakayama Shouta M.M.、Bortey-Sam Nesta、Oroszlany Balazs、Tongo Isioma、Enuneku Alex Ajeh、Ozekeke Ogbeide、Ainerua Martins Oshioriamhe、Fasipe Iriagbonse Priscillia、Ezemonye Lawrence Ikechukwu、Mizukawa Hazuki、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 151 Pages: 98～108
  • DOI: 10.1016/j.ecoenv.2017.12.069
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A glycomics approach to discover novel renal biomarkers in birds by administration of cisplatin and diclofenac to chickens (2018)
  • Author(s): Ishii C、Ikenaka Y、Ichii O、Nakayama S M M、Nishimura S-I、Ohashi T、Tanaka M、Mizukawa H、Ishizuka M
  • Journal Title: Poultry Science Volume: - Pages: pey016
  • DOI: https://doi.org/10.3382/ps/pey016
  • Peer Reviewed / Open Access
• [Journal Article] Human Health Risk from Consumption of Marine Fish Contaminated with DDT and its Metabolites in Maputo Bay, Mozambique. (2018)
  • Author(s): Thompson L.A, Ikenaka Y, Yohannes Y.B, Ichise T, Ito G, Bortey-Sam N, van Vuren J.J, Wepener V, Smit N.J, Darwish W.S, Nakayama S.M.M, Mizukawa H, Ishizuka M.
  • Journal Title: Bull. Environ. Contam. Toxicol Volume: 印刷中 Pages: 印刷中
  • DOI: 10.1007/s00128-018-2323-7.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana (2018)
  • Author(s): Bortey-Sam Nesta、Ikenaka Yoshinori、Akoto Osei、Nakayama Shouta M.M.、Asante Kwadwo A.、Baidoo Elvis、Obirikorang Christian、Mizukawa Hazuki、Ishizuka Mayumi
  • Journal Title: Environ Pollut. Volume: 235 Pages: 163～170
  • DOI: 10.1016/j.envpol.2017.12.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle (2018)
  • Author(s): Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo JT, Saengtienchai A, Mizukawa H, Ishizuka M
  • Journal Title: JVMS Volume: 80 Pages: 375-381
  • DOI: 10.1292/jvms.17-0410.
  • Peer Reviewed / Open Access
• [Journal Article] β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line. (2018)
  • Author(s): Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Thompson LA, Ishizuka M
  • Journal Title: Environ Sci Pollut Res Int. Volume: 25 Pages: 6320-6328
  • DOI: 10.1007/s11356-017-0977-z.
  • Peer Reviewed / Open Access
• [Journal Article] 鳥類で起こっているケミカルハザードとそのメカニズム (2017)
  • Author(s): 中山翔太、水川葉月、池中良徳、石塚真由美
  • Journal Title: 日本野生動物医学会誌 Volume: 22 Pages: 69-72
  • Peer Reviewed / Open Access
• [Journal Article] 鳥類の鉛中毒の分析と原因 (2017)
  • Author(s): 石井千尋、中山翔太、水川葉月、池中良徳、石塚真由美
  • Journal Title: 中毒研究 Volume: 30 Pages: 363-367
  • Peer Reviewed / Open Access
• [Journal Article] Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model (2017)
  • Author(s): Sasaki Noboru、Ishi Kazuhiro、Kudo Nobuki、Nakayama Shouta M. M.、Nakamura Kensuke、Morishita Keitaro、Ohta Hiroshi、Ishizuka Mayumi、Takiguchi Mitsuyoshi
  • Journal Title: PLOS ONE Volume: 12 Pages: e0188093
  • DOI: 10.1371/journal.pone.0188093
  • Peer Reviewed / Open Access
• [Journal Article] Multidisciplinary field research in Kabwe, Zambia, towards better understanding of lead contamination of the city - A short report from a field survey (2017)
  • Author(s): Uchida Yoshitaka、Banda Kawawa、Nyambe Imasiku、Hamamoto Toru、Yoshii Yui、Munthali Kabenuka、Mwansa Mukuka、Mukuka Moses、Mutale Mubanga、Yabe John、Toyomaki Haruya、Beyene Yohannes Yared、Nakayama Shouta M. M.、Naruse Nobuyasu、Ishizuka Mayumi、Takahashi Yukihiro
  • Journal Title: bioRxiv Volume: - Pages: -
  • DOI: https://doi.org/10.1101/096164
  • Open Access / Int'l Joint Research
• [Journal Article] Contamination Levels and Sources of Heavy Metals and a Metalloid in Surface Soils in the Kumasi Metropolis, Ghana (2017)
  • Author(s): Akoto O, Bortey-Sam N, Ikenaka Y, Nakayama SMM, Baidoo E, Yohannes YB, Ishizuka M
  • Journal Title: Journal of Health and Pollution Volume: 15 Pages: 28-39
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lead exposure in raptors from Japan and source identification using Pb stable isotope ratios (2017)
  • Author(s): Ishii Chihiro、Nakayama Shouta M.M.、Ikenaka Yoshinori、Nakata Hokuto、Saito Keisuke、Watanabe Yukiko、Mizukawa Hazuki、Tanabe Shinsuke、Nomiyama Kei、Hayashi Terutake、Ishizuka Mayumi
  • Journal Title: Chemosphere Volume: 186 Pages: 367～373
  • DOI: 10.1016/j.chemosphere.2017.07.143
  • Peer Reviewed / Open Access
• [Journal Article] Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores (2017)
  • Author(s): Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
  • Journal Title: Toxicological Sciences Volume: 158 Pages: 90～100
  • DOI: 10.1093/toxsci/kfx072
  • Peer Reviewed / Open Access
• [Journal Article] Anthropogenic and Naturally Produced Brominated Phenols in Pet Blood and Pet Food in Japan (2017)
  • Author(s): Mizukawa Hazuki、Nomiyama Kei、Nakatsu Susumu、Yamamoto Miyuki、Ishizuka Mayumi、Ikenaka Yoshinori、Nakayama Shouta M.M.、Tanabe Shinsuke
  • Journal Title: Environ. Sci. Technol. Volume: 51 Pages: 11354～11362
  • DOI: 10.1021/acs.est.7b01009
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa (2017)
  • Author(s): Yohannes Yared Beyene、Ikenaka Yoshinori、Ito Gengo、Nakayama Shouta M. M.、Mizukawa Hazuki、Wepener Victor、Smit Nico J.、Van Vuren Johan H. J.、Ishizuka Mayumi
  • Journal Title: Environmental Science and Pollution Research Volume: 24 Pages: 23763～23770
  • DOI: 10.1007/s11356-017-9911-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Concentrations and Human Health Risk Assessment of DDT and Its Metabolites in Free-range and Commercial Chicken Products from KwaZulu-Natal, South Africa (2017)
  • Author(s): Thompson LA, Ikenaka Y, Yohannes YB, van Vuren JJ, Wepener V, Smit NJ, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M
  • Journal Title: Food Additives and Contaminants: Part A Volume: 34 Pages: 1959-1969
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sediment Metal Contamination in the Kafue River of Zambia and Ecological Risk Assessment (2017)
  • Author(s): M’kandawire Ethel、Choongo Kennedy、Yabe John、Mwase Maxwell、Saasa Ngonda、Nakayama Shouta M. M.、Bortey-Sam Nesta、Blindauer Claudia A.
  • Journal Title: Bulletin of Environmental Contamination and Toxicology Volume: 99 Pages: 108～116
  • DOI: 10.1007/s00128-017-2089-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 非実験動物における化学物質代謝能の特徴と種差 (2017)
  • Author(s): Mizukawa Hazuki、Ikenaka Yoshinori、Kakehi Mayu、Nakayama Shouta、Ishizuka Mayumi
  • Journal Title: YAKUGAKU ZASSHI Volume: 137 Pages: 257～263
  • DOI: 10.1248/yakushi.16-00230-2
  • Peer Reviewed / Open Access
• [Journal Article] Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Yared Beyene Yohannes, Yutaka Watanuki, Masaaki Fukuwaka, and Mayumi Ishizuka
  • Journal Title: JVMS Volume: 79 Pages: 807-814
  • DOI: 10.1292/jvms.16-0441.
  • Peer Reviewed / Open Access
• [Journal Article] Organochlorine pesticide contamination of foods in Africa: incidence and public health significance (2017)
  • Author(s): THOMPSON Lesa A.、DARWISH Wageh Sobhy、IKENAKA Yoshinori、NAKAYAMA Shouta M. M.、MIZUKAWA Hazuki、ISHIZUKA Mayumi
  • Journal Title: JVMS Volume: 79 Pages: 751～764
  • DOI: 10.1292/jvms.16-0214
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Monitoring Lead (Pb) Pollution and Identifying Pb Pollution Sources in Japan Using Stable Pb Isotope Analysis with Kidneys of Wild Rats (2017)
  • Author(s): Nakata Hokuto、Nakayama Shouta、Oroszlany Balazs、Ikenaka Yoshinori、Mizukawa Hazuki、Tanaka Kazuyuki、Harunari Tsunehito、Tanikawa Tsutomu、Darwish Wageh、Yohannes Yared、Saengtienchai Aksorn、Ishizuka Mayumi
  • Journal Title: Int. J. Environ. Res. Public Health Volume: 14 Pages: 56～56
  • DOI: 10.3390/ijerph14010056
  • Peer Reviewed / Open Access
• [Journal Article] Trace Element Contamination in Tissues of Four Bird Species from the Rift Valley Region, Ethiopia (2017)
  • Author(s): Yohannes Yared Beyene、Ikenaka Yoshinori、Nakayama Shouta M. M.、Mizukawa Hazuki、Ishizuka Mayumi
  • Journal Title: Bulletin of Environmental Contamination and Toxicology Volume: 98 Pages: 172～177
  • DOI: 10.1007/s00128-016-2011-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia. (2017)
  • Author(s): Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: Sci. Total. Environ. Volume: 574 Pages: 1389-1395
  • DOI: 10.1016/j.scitotenv.2016.08.056.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] ザンビア・カブエ鉱床における鉛汚染問題とその解決に向けた取り組み-KAbwe Mine Pollution Amelioration Initiative (KAMPAI Project)- (2018)
  • Author(s): 中山翔太、水川葉月、池中良徳、石塚真由美
  • Organizer: 第3回 北大部局間横断シンポジウム
  • Invited
• [Presentation] Lead levels in eggs in Kabwe, Zambia: implication of human exposure (2018)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka
  • Organizer: Society of Toxicology’s 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] Comparison of Food Products Contaminated by DDTs in South Africa and Mozambique (2017)
  • Author(s): Lesa A. Thompson, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka
  • Organizer: 19th International Conference on One Health
  • Int'l Joint Research
• [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 第26回環境化学討論会
• [Presentation] A Pilot Study on Exposure of Lead (Pb) and Its Blood Level Burden in Children from Kabwe, Zambia: Implication to the General Population (2017)
  • Author(s): Yared B. Yohannes, Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 第26回環境化学討論会
• [Presentation] Introduction of “The project for Visualization of impact of chronic / latent chemical hazard and Geo-Ecological Remediation” in Kabwe, Zambia (2017)
  • Author(s): Hokuto Nakata, Yoshitaka Uchida, Kaampwe Muzandu, Kawawa Banda, Shouta M.M. Nakayama, John Yabe, Toshifumi Igarashi, Mayumi Ito, Imasiku Nyambe, Mayumi Ishizuka
  • Organizer: The sixth Zambia Water Forum and Exhibition
  • Int'l Joint Research
• [Presentation] 高次栄養段階生物への化学物質の感受性の種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 2017年度第31回講演会
• [Presentation] Studies on polycyclic aromatic hydrocarbons formation in heat-treated meat (2017)
  • Author(s): Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] Utility evaluation for stable Pb isotopes analysis using potential sentinel animals to identify Pb pollution sources (2017)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: International Conference on Geology, Mining, Mineral and Groundwater Resources of the Sub-Saharan Africa
  • Int'l Joint Research
• [Presentation] 全国規模での鳥類への鉛曝露：曝露指標として骨の利用の可能性 (2017)
  • Author(s): 石井千尋，中山翔太，池中良徳，Kataba Andrew，齊藤慶輔，渡辺有希子，槇納好岐，松川岳久，久保田章乃，横山和仁，水川葉月，平田岳史，石塚真由美
  • Organizer: 第23回日本野生動物医学会大会
• [Presentation] Heavy metal residues in some ready-to-eat meat products marketed in Egypt (2017)
  • Author(s): Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Trends of childhood blood lead levels and remedial options in Kabwe, Zambia (2017)
  • Author(s): John Yabe, Haruya Toyomaki, Shouta MM Nakayama, Yared B. Yohannes,Kaampwe Muzandu, Andrew Kataba, Kennedy Choongo, Russell Dowling, Jack Caravanos, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] The relationship of Blood Lead Levels between mothers and infants in Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Wild rat’s bio-distribution analysis for pesticide DDT from South Africa (2017)
  • Author(s): Tetsuro Ogawa, Yoshinori Ikenaka, Yared B Yohannes, Lesa Thompson, Johan van Vuren, Victor Wepener, Nico J Smit, Wynand Vlok, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research
• [Presentation] 鳥類医学の発展に向けた新規腎障害マーカーの探索 (2017)
  • Author(s): 石井千尋, 池中良徳, 川合佑典, 市居修, 中山翔太, 西村紳一郎, 大橋哲, 田中誠一, 齊藤慶輔, 渡邊有希子, 水川葉月, 石塚真由美
  • Organizer: 日本鳥学会２０１７年度大会
• [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Discovery of renal biomarker in birds by transcriptome analysis of kidney tissues and glycomics analysis of plasma following renal damage in chicken model. (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] “First, do no harm” ? balancing the benefits of malaria control against the toxic effects of DDT use (2017)
  • Author(s): Lesa THOMPSON, Yoshinori IKENAKA, Yared YOHANNES, Atnafu ASSEFA, Johan VAN VUREN, Victor WEPENER, Nico SMIT, Wynand VLOK, Wageh Sobhy DARWISH, Shouta NAKAYAMA, Hazuki MIZUKAWA and Mayumi ISHIZUKA
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Effect of DDTs on gallinacins in the avian immune system (2017)
  • Author(s): Lesa Thompson, Yoshinori Ikenaka, Yared Yohannes, Johan van Vuren, Victor Wepener, Nico Smit, Atnafu Assefa, Wageh Sobhy Darwish, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
  • Int'l Joint Research
• [Presentation] Discovery of renal biomarkers in birds by transcriptome analysis and glycomics analysis following kidney injury in chicken model (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
  • Int'l Joint Research
• [Presentation] Current trends of blood lead levels in Kabwe, Zambia (2017)
  • Author(s): Yared BeyeneYohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Hokuto Nakata, Kaampwe Muzandu, Andrew Kataba, Golden Zyambo, Hazuki Mizukawa, Yoshinori Ikenaka, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Extent of lead exposure in mothers and infants living around a "closed" lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Reliability of stable lead isotope analysis for lead source identification and verifying biological fractionation of lead isotopes in goats and chicken (2017)
  • Author(s): Hokuto Nakata, Shouta MM Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh S Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Practical system integration for local community participation in lead contamination assessment in Kabwe, Zambia (2017)
  • Author(s): Shinsaku Nakamura, Kazuyo Hirose, Tomomi Takeda, Yoshitaka Uchida, Hokuto Nakata, Shouta MM Nakayama, Mayumi Ishizuka, John Yabe, Mayumi Ito, Toshifumi Igarashi
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Local distribution of Pb in mice using bioimaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) (2017)
  • Author(s): Shouta MM Nakayama, Masao Togao, Yoshinori Ikenaka, Hazuki Mizukawa, Yoshiki Makino, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Takafumi Hirata, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Evaluation of utility for stable lead isotope ratios to identify lead sources and verifying biological fractionation of lead isotopes in goats and chickens (2017)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Elevated Blood Lead Levels among Children, Infants and Mothers in Kabwe, Zambia (2017)
  • Author(s): Yared Beyene Yohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Kaampwe Muzandu, Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Hokuto Nakata, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Evaluation of indoor residual spraying DDT for mosquito control: Tissue distribution and gene expression profiling in rat tissues (2017)
  • Author(s): Emmanuel Temiotan Ogbomida, Alex Ajeh Enuneku, Yoshinori Ikenaka, Yared Beyene Yohannes, Wageh Sobhy Darwish, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 環境ホルモン学会第20回研究発表会
• [Book] 9th International Toxicology Symposium in Africa (2017)
  • Author(s): Ikenaka Y, Darwish WS, Johan JV, Wepner V, Moundipa PF, Akoto O, Ikechukwu EL, Ogbomida E, Enuneku A, Beyene Y, Yabe J, Nakayama SMM, Mizukawa H, Ishizuka M
  • Total Pages: 155
  • Publisher: Syobunsha
  • ISBN: 978-0-620-76799-6
• [Book] KAbwe Mine Pollution Amelioration Initiative Project (KAMPAI) (2017)
  • Author(s): Nakayama SMM, Yabe J, Nakata H & Ishizuka M
  • Total Pages: 68
  • Publisher: Syobunsha
  • ISBN: 978-4-909032-00-3
• [Book] トキシコロジー第3版（7章 環境毒性） (2017)
  • Author(s): 石塚真由美、中山翔太、鑪迫典久
  • Total Pages: 13
  • Publisher: 朝倉書店
• [Remarks] 北海道大学 大学院獣医学研究院 毒性学教室
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks] ケミカルハザード問題の克服に向けた国際コミッション
  • URL: http://aa.vetmed.hokudai.ac.jp/
• [Remarks] 北海道大学 大学院獣医学研究院
  • URL: https://www.vetmed.hokudai.ac.jp/
• [Remarks] ザンビアにおける鉛汚染のメカニズムの解明と健康・経済リスク評価手法および予防・修復技術の開発
  • URL: http://satreps-kampai.vetmed.hokudai.ac.jp/