2017 Fiscal Year Final Research Report
Elucidation of useful livestock/poultry for Pb source estimation and its molecular mechanisms underlying species differences by integrated metallomics approaches
| Project/Area Number |
16K16197
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
Ishizuka Mayumi 北海道大学, 大学院獣医学研究院, 教授
Ikenaka Yoshinori 北海道大学, 大学院獣医学研究院, 准教授
Mizukawa Hazuki 北海道大学, 大学院獣医学研究院, 助教
Hirata Takafumi 東京大学, 大学院理学系研究科, 教授
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 鉛 / 汚染源推定 / 安定同位体比 / 家畜・家禽 / ヤギ / ニワトリ / 歩哨動物 / LA-ICP-MS |
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| Outline of Final Research Achievements |
According to WHO, approximately 230,000 people annually die mainly from lead (Pb) poisoning derived from mineral deposits and affect the intellectual development of more than 600,000 children, but useful methods for estimating pollution sources have not been established. In this study, we aimed to elucidate useful livestock and poultry species for source estimation of Pb contamination. From the high precision lead isotope ratio analysis, it was revealed that it is possible to estimate the source of Pb contamination by using goats and chickens distributed in developing countries including Africa and also used as human food sources. Local distribution of Pb in mice was analyzed by LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry). High Pb accumulation in the hippocampus area of the brain and Pb accumulation at a higher concentration than in the cortex than the medulla of the kidney was revealed.
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| Free Research Field |
毒性学、獣医毒性学
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