Evaluation of the effect of chemical exposure using metabolome analysis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16198
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Chiba University
• Principal Investigator: Eguchi Akifumi 千葉大学, 予防医学センター, 助教 (70595826)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: メタボロミクス / 残留性有機汚染物質 / 重金属 / コホート調査

Outline of Final Research Achievements

In this study, we investigated the exposure effect of environmental pollutants such as heavy metals and persistent organic pollutants (POPs) on humans by using metabolome analysis that comprehensively analyzes low molecular compounds in serum and urine; We tried to elucidate by analyzing the relationship between profiles of metabolome and residual concentrations of chemical substances.
In this study, residue levels of PCBs were related to glutathione and amino acid metabolism in maternal serum and the amino acid metabolism and ubiquinone and other terpenoid-quinone biosynthesis (energy metabolism) in cord serum, indicating disruption of metabolic pathways by PCB exposure in pregnant women and fetuses. Residue levels of Pb were associated with ABC transport, possibly related to the disruption of small-molecule transport in the kidney; amino acid, porphyrin, and chlorophyll metabolism; and possibly, the heme biosynthetic pathway.

Free Research Field

環境分析化学