2017 Fiscal Year Final Research Report
Assay system for screening food and natural substances that have antihyperuricemic activity: uric acid production in cultured hepaticytes
| Project/Area Number |
16K16273
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Utsunomiya University |
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Principal Investigator |
Adachi Shin-ichi 宇都宮大学, 学内共同利用施設等, 特任助教 (10747041)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 高尿酸血症 |
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| Outline of Final Research Achievements |
We tried to search for compounds that inhibit uric acid (UA) production in an in vitro assay system employing the cultured hepatocytes in order to quest novel factors in foods and natural resource effective for prevention and remediation of hyperuricemia. We found several candidates and attempted to examine the effects of them on antihyperuricemia in the model mice by purine-bodies administration. As a result, taxifolin, isorhamnetin and urolithin A dose-dependently and significantly suppressed the increase in plasma UA concentration. They demonstrated to show antihyperuricemic effect by directly suppressing xanthine oxidase activity.
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| Free Research Field |
生活科学
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