Comprehensive analysis of the effects of mild dietary magnesium deficiency on the hepatic nutrition metabolism in rats : a study based on a magnesium intake in Japan.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16275
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: The University of Tokyo
• Principal Investigator: ISHIJIMA Tomoko 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (80568270)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 軽度マグネシウム欠乏 / ラット / 肝臓 / 栄養素代謝 / トランスクリプトーム解析

Outline of Final Research Achievements

In experiments with rats, bodily magnesium (Mg) state largely depended on dietary Mg quantity; serum Mg was lower in 0.02% Mg diet group than 0.04% Mg diet group, although common serum indexes were not changed in 0.02% Mg diet group compared to control diet group.
Genetically, however, the numbers of significantly changed hepatic genes were much more in 0.02% Mg diet group than in 0.04% Mg diet group. In both cases, the changed genes included those for lipid-glucose metabolism, immune response, and cell adhesion. It is thus suggested that even a small decrease a dietary Mg quantity can influence the gene expressions for these physiologically important events in the liver.

Free Research Field

栄養生化学