2017 Fiscal Year Final Research Report
The effect of an amino acid sensor GCN2 on the development of type 2 diabetes mellitus during high fat diet feeding
| Project/Area Number |
16K16277
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
Kanno Ayumi 神戸大学, 医学研究科, 医学研究員 (60757285)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 糖尿病 / アミノ酸 |
|---|
| Outline of Final Research Achievements |
Our objective was to elucidate the mechanism of GCN2 activation in pancreatic β-cells under high fat feeding. We have demonstrated that insulin translation was enhanced and GCN2 was activated in mice islets fed a high fat diet.
We discovered that general amino acids were decreased and uncharged tRNAs were increased in the islets of wild type mice fed a high fat diet, compared with those of mice fed a normal chow diet. However, these changes were not seen in other tissues. We considered that during high fat feeding, increased systemic insulin demand increases insulin biosynthesis in pancreatic β-cells, which decreased amino acids and increased tRNA levels, and lead to GCN2 activation.
|
| Free Research Field |
糖尿病学
|
