2018 Fiscal Year Final Research Report
The impact of essential fatty acids on anxiety-related behaviors in mice
| Project/Area Number |
16K16280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Research Collaborator |
Kanno Chiaki
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 多価不飽和脂肪酸 / 不安 |
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| Outline of Final Research Achievements |
To reveal brain mechanism that consumption of an n-6 fatty acid-rich and n-3 fatty acid-poor diet induces anxious behaviors, we peformed behavioral and neurochemical analyses using mice. This study suggests that induced dopamine release in the ventral striatum is one of the causes that induce anxious behaviors in mice fed the n-6 fatty acid-rich and n-3 fatty acid-poor diet.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
多くの先進国において、n-6脂肪酸を豊富に含む植物油などの摂取増加、およびn-3脂肪酸を豊富に含む魚などの摂取減少が進行しており、食中脂肪酸の高n-6 /低n-3状態は世界規模で深刻な問題となっている。このような食生活の変化が進行する現代社会において、本研究は不安障害の予防と新規治療法の開発に向けて基礎的知見を提供しうるものと期待される。
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