2017 Fiscal Year Final Research Report
Analysis of the mechanism of anti-diabetic effect by polyacetylenes from the Apiaceae vegetables.
| Project/Area Number |
16K16284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Iwate Medical University |
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Principal Investigator |
YOSHIDA Jun 岩手医科大学, 教養教育センター, 助教 (20611007)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | ポリアセチレン化合物 / falcarindiol / GSK-3β / セリ科植物 / 糖新生 / 機能性物質 / インスリン |
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of the anti-diabetic effect of falcarindiol isolated from Apiaceae family vegetables. Falcarindiol suppressed glucose production in rat hepatoma H4ⅡE cells. Falcarindiol also increased the level of inhibitory phosphorylation of GSK-3β in H4IIE cells. These results indicate that several Apiaceae family vegetables containing falcarindiol could be a useful food ingredient against type-2 diabetes.
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| Free Research Field |
食生活学
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