2017 Fiscal Year Final Research Report
Molecular tension sensors visualize cell mechanical signal under mechanical stress
| Project/Area Number |
16K16387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | メカノシグナル / 分子張力センサー / 機械刺激 |
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| Outline of Final Research Achievements |
We developed the shear stress applying system on the microscope and visualized focal adhesions motion and mechanical signal on real time. Our system revealed that focal adhesions and high mechanical signal are aligned to the parallel direction of flow direction. These results suggest integrin molecules use catch bond system.
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| Free Research Field |
生体医工
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