世界最小径再生型人工血管の開発とその成長性の可能性

2016 Fiscal Year Research-status Report

• Project/Area Number: 16K16388
• Research Institution: Hiroshima University
• Principal Investigator: 石井 大造 広島大学, 病院(医), 医科診療医 (30773775)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 人工血管 / バイオチューブ / 生体内組織形成術

Outline of Annual Research Achievements

生体内組織形成術で作成した世界最小径人工血管（マイクロバイオチューブ）のラットへの移植を着実に実施してきた。移植後急性期のデータをまとめた形で、論文を発表した。（Ishii D, et al. Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography. J Artif Organs. 19(3). 262-9. 2016）
また今までのデータをまとめて、XLIII　Annual Congress of the European Society for Artificial Organsで2演題、（IBTA-fabricated MicroBiotube vascular grafts met 1 year’s perfect patency in a rat model, One result about growth adaptation of a Biotube vascular graft in a rat model） 、またAmerican Heart Association Scientific Session 2016で1演題（Absolute perfect patency of In Vivo Tissue-Engineered Vascular Grafts with an Ultra Small Diameter of 0.6 mm (MicroBiotubes) in a rat model for 1 year）、それぞれ2回の国際学会で発表した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

着実に移植は実施できており、画像follow upも行うことができている。

Strategy for Future Research Activity

長期間のfollow up結果をまとめて、論文で発表する予定。

Causes of Carryover

物品費及びその他の使用金額が、予定よりも少なく出来たため。

Expenditure Plan for Carryover Budget

適宜、物品費、旅費、及び論文執筆時の英文校正費等に当てる予定。

Research Products

• [Journal Article] Development of in vivo tissue-engineered microvascular grafts with an ultra small diameter of 0.6 mm (MicroBiotubes): acute phase evaluation by optical coherence tomography and magnetic resonance angiography. (2016)
  • Author(s): Ishii D, Enmi J, Moriwaki T, Ishibashi-Ueda H, Kobayashi M, Iwana S, Iida H, Satow T, Takahashi JC, Kurisu K, Nakayama Y.
  • Journal Title: J Artif Organs. Volume: 19(3) Pages: 262-269
  • DOI: 10.1007/s10047-016-0894-9.
  • Peer Reviewed
• [Presentation] 生体内組織形成術による世界最小径人工血管（マイクロバイオチューブ）の開発 (2016)
  • Author(s): 石井大造、圓見純一郎、岩井良輔、飯田秀博、栗栖 薫、中山泰秀
  • Organizer: 第54回日本人工臓器学会大会
  • Place of Presentation: 米子
  • Year and Date: 2016-11-23 – 2016-11-25
• [Presentation] Absolute perfect patency of In Vivo Tissue-Engineered Vascular Grafts with an Ultra Small Diameter of 0.6 mm (MicroBiotubes) in a rat model for 1 year (2016)
  • Author(s): Ishii D, Enmi J, Iida H, Kurisu K, Nakayama Y
  • Organizer: American Heart Association Scientific Session 2016
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] IBTA-fabricated MicroBiotube vascular grafts met 1 year’s perfect patency in a rat model (2016)
  • Author(s): Ishii D, Enmi J, Iida H, Kurisu K, Nakayama Y
  • Organizer: XLIII Annual Congress of the European Society for Artificial Organs
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2016-09-14 – 2016-09-17
  • Int'l Joint Research
• [Presentation] One result about growth adaptation of a Biotube vascular graft in a rat model (2016)
  • Author(s): Ishii D, Enmi J, Iida H, Kurisu K, Nakayama Y
  • Organizer: XLIII Annual Congress of the European Society for Artificial Organs
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 2016-09-14 – 2016-09-17
  • Int'l Joint Research