Development of microvascular grafts with an ultra small diameter of 0.6mm

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Hiroshima University
• Principal Investigator: Ishii Daizo 広島大学, 病院(医), 医科診療医 (30773775)
• Research Collaborator: Nakayama Yasuhide 国立循環器病研究センター, 研究所医工学材料研究室, 室長 (50250262)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: biotube / vascular graft / small calibre / biomaterial

Outline of Final Research Achievements

The long-term patency of small calibre “microbiotubes” with an inner diameter of 0.6 mm is described. No small calibre grafts of acceptable quality are currently available, and it has been difficult to maintain the patency of artificial vessels with an inner diameter of < 3 mm. In this study, 75% of microbiotubes used as allogenic grafts in rats remained patent at 12 months. It is believed that this study makes a significant contribution to the literature as it demonstrates that microbiotubes have high compatibility, stability, and durability as long-term replacement grafts and may be usefully applied to microsurgery.

Free Research Field

脳神経外科