2020 Fiscal Year Final Research Report
Evaluation of local arteriosclerosis using shear wave elastography
| Project/Area Number |
16K16432
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
Iwamoto Erika 札幌医科大学, 保健医療学部, 講師 (40632782)
|
|---|
| Project Period (FY) |
2016-04-01 – 2021-03-31
|
| Keywords | shear-wave elastography / arterial stiffness / arteriosclerosis / menstrual cycle / aerobic exercise |
|---|
| Outline of Final Research Achievements |
The purpose of this study was to verify the evaluation of arteriosclerosis using the shear wave elastography (ultrasound tissue elastic imaging) which is a new imaging that images local arterial stiffness. Specifically, we aimed to clarify 1) whether Young's modulus measured by shear wave elastography more reflects "structural factors" such as the structure of blood vessel walls or "functional factors" such as vascular reactivity and 2) the physiological factors that influence Young's modulus. We found that the changes in estradiol during menstrual cycle in the young women and acute aerobic exercise did not affect Young's modulus. These results suggest that arterial stiffness measured by shear wave elastography may more reflect arterial structural factors compared to the functional factors.
|
| Free Research Field |
運動生理学
|
| Academic Significance and Societal Importance of the Research Achievements |
動脈スティフネスは心血管疾患の発症リスクとの関連が強く，その評価は臨床的意義が高い．ただし，従来から用いられている動脈スティフネスの指標は，運動，エストロゲンなどのホルモンの影響，血圧，食事，緊張などの影響を受けやすいことが報告されており，動脈硬化検査にて考慮すべき問題である．これに対して，剪断波エラストグラフィは，機能的要素の影響を受けにくく，かつ局所の器質的な硬さを非侵襲的に測定できることが示され，心血管疾患予防のための有用なツールとなる可能性が示された．
|
