The role of corticotropin releasing hormone in acquisition of motor learning

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K16486
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental mechanisms and the body works
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: TAKEUCHI Eri 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第四部, 流動研究員 (70712777)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: コルチコトロピン放出ホルモン / 運動学習

Outline of Final Research Achievements

In our previous study, we found that the acquisition of motor learning was enhanced by injection of corticotropin releasing hormone (CRH) into the cerebellum. It suggests that exogenous CRH enhances the acquisition of motor learning. In this study, we focused on the role of endogenous CRH in the acquisition of motor learning. We found that CRH mRNA in the cerebellum was increased after the mice were received restraint stress. Moreover, the mice received restraint stress showed enhanced acquisition of motor learning. These results suggest that endogenous CRH also has a positive effect on motor learning.

Free Research Field

複合領域　身体教育学