Effect of exercise on brown adipose tissue and its therapeutic application to dyslipidemia

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K16572
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: Nirengi Shinsuke 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70741156)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 褐色脂肪組織 / 近赤外線分光法 / 運動

Outline of Final Research Achievements

We have found and validated that near-infrared time-resolved spectroscopy can evaluate human brown adipose tissue (BAT) density. We have reported that BAT density is associated with age, body fat (subcutaneous and visceral), and outdoor temperature in a cross-sectional study. Several functional foods that increase BAT density have been also reported.
In animal studies, although the blood levels of triglyceride and cholesterol were increased by the high-fat diet, high-intensity intermittent exercise improved this condition. Furthermore, this exercise tends to increase the expression of uncoupling protein 1 in BAT. In recent years, it has been reported that the liquid factor derived from BAT may cross-talk with other tissues. Therefore, it is necessary to study in detail the relation between BAT and lipid metabolism.

Free Research Field

運動生理学

Academic Significance and Societal Importance of the Research Achievements

これまで評価困難であったヒトBATの簡易な評価法の考案および妥当性の検証を行った。BATに影響する因子を探索することができた。運動によりBAT活性が増加する可能性を見出すことができた。これらの結果は、今後、BATと生活習慣病との関連の詳細な検討や、生活習慣を是正するための基礎データとなりうる。