2017 Fiscal Year Final Research Report
Studies on the physiological role of ascorbic acid in SOD1/Akr1a double knockout mice with increased oxidative stress
| Project/Area Number |
16K16592
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Yamagata University |
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Principal Investigator |
Homma Takujiro 山形大学, 大学院医学系研究科, 助教 (70743566)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 酸化ストレス / スーパーオキシド / ビタミンC |
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| Outline of Final Research Achievements |
To elucidate the physiological role of superoxide and ascorbic acid in vivo, we have established the SOD1/Akr1a double knockout (DKO) mice.The DKO mice had serious phenotype with heightened oxidative stress. After AsA withdrawal, all DKO mice died within two weeks. The AsA withdrawal for a week significantly increased plasma ALT levels but had no effect on cardiac function in the DKO mice.
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| Free Research Field |
生化学・分子生物学
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